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1.
Surg Endosc ; 36(6): 4470-4478, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-34697682

RESUMO

BACKGROUND: Laparoscopic liver resection of tumors located in segments 7 and 8 are considered a complex resection. The aim of this study was to compare the intraoperative and early postoperative outcomes of patients operated by pure laparoscopic (PLS) vs hand-assisted laparoscopic surgery (HALS). METHODS: From January 2003 to January 2021, we included patients with minimally invasive surgery for lesions located in segments 7 and 8. To overcome selection bias, we performed 1:1 propensity score matching (PSM) between HALS and PLS cohorts, including 30 patients in each of the groups. Of the 60 patients who underwent PSM, we compared the first 30 patients with the following 30 patients. RESULTS: A total of 79 LLRs were performed, 46 by HALS and 33 by PLS. After PSM, in the PLS cohort, cirrhosis was more frequent (33.3% vs. 13.3%, p = 0.02). The surgical time, blood loss, Pringle maneuver, clamping time, and morbidity were similar between both groups, but with a lower hospital stay in the PLS group (3 days vs. 4 days, p < 0.01). In the first 30 patients who underwent LLR, the use of PLS was lower than the use of HALS, increasing due to the learning curve (16.7% in the first period vs. 83.3% in the second period; p < 0.01). The hospital stay was lower in the second period due to the more frequent use of PLS (3 vs. 4 days, p < 0.01). CONCLUSION: PLS presents similar intraoperative and early postoperative results with lower hospital stay for lesions located in segments 7 and 8 compared to HALS. In centers with experience in LLRs, PLS could be performed safely in these segments.


Assuntos
Laparoscopia , Neoplasias Hepáticas , Hepatectomia/métodos , Humanos , Laparoscopia/métodos , Tempo de Internação , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/cirurgia , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Pontuação de Propensão , Estudos Retrospectivos
2.
Rev. esp. enferm. dig ; 111(9): 662-666, sept. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-190348

RESUMO

Introducción: la relación entre la gastrectomía vertical laparoscópica (GVL) y el reflujo gastroesofágico (RGE) es aún controvertida, por lo que su investigación tiene gran interés para llegar a conclusiones definitivas. Nuestro objetivo es determinar si la GVL modifica el RGE pH-métrico de los pacientes obesos y, en caso de que así sea, analizar algunos factores que pudieran explicarlo. Pacientes y métodos: incluimos los primeros 26 pacientes que recibieron una GVL en nuestro centro. Se realizaron un tránsito baritado, una pH-metría ambulatoria de 24 horas y una manometría intraluminal esofágica (MIE) con cuatro canales previamente y al año de la operación. Resultados: de los datos pH-métricos, el índice de DeMeester mostró un aumento significativo (p = 0.028) tras la intervención, mientras que los demás parámetros fueron similares. Por otra parte, se observó que el 50% de los pacientes con RGE pH-métrico preoperatorio mostraron tasas normales al año de la operación. En la MIE objetivamos que la presión del esfínter esofágico inferior (EEI) disminuyó, así como la amplitud media de las ondas en el tercio distal esofágico (p = 0,007 y p = 0,025, respectivamente). En el estudio radiológico la tasa de hernias de hiato "de novo" fue del 36,4%. Conclusión: la GVL determina un aumento leve del RGE, probablemente relacionado con la aparición de hernias de hiato así como con una disminución de la presión del EEI y de la capacidad de barrido esofágico. Sin embargo, no debe contraindicarse la GVL a pacientes con RGE preoperatorio pH-métrico pues puede negativizarse tras la operación


Introduction: the relationship between laparoscopic vertical gastrectomy (LVG) and gastroesophageal reflux (GER) is still controversial. Therefore, its study is of great interest in order to obtain definitive conclusions. The goal of the study was to establish whether LVG modifies pH-metric GER in obese patients and to analyze the associated factors. Patients and methods: the first 26 patients who underwent LVG in our institution were enrolled in the study. A barium swallow, 24-hour ambulatory pH-metry and four-channel intraluminal esophageal manometry (IEM) were all performed before and one year after surgery. Results: among the pH-metric data, there was a significant increase in the DeMeester index after the procedure (p = 0.028), while other parameters remained unchanged. Furthermore, 50% of patients with preoperative pH-metric GER had normal values at one year after surgery. IEM showed a decrease in lower esophageal sphincter (LES) pressure and in the mean wave amplitude at the distal third of the esophagus (p = 0.007 and p = 0.025, respectively). The rate of newly-developed hiatal hernias in the radiographic study was 36.4%. Conclusion: LVG mildly increases GER, which is likely related to the development of hiatal hernias and a decrease in LES pressure and esophageal sweep. However, LVG should not be contraindicated for patients with preoperative pH-metric GER, as this may clear after the procedure


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Refluxo Gastroesofágico/cirurgia , Gastrectomia/estatística & dados numéricos , Laparoscopia/estatística & dados numéricos , Obesidade Mórbida/cirurgia , Refluxo Gastroesofágico/fisiopatologia , Alcalinização/análise , Concentração de Íons de Hidrogênio , Manometria/métodos , Estudos Prospectivos
3.
Rev Esp Enferm Dig ; 111(9): 662-666, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31257899

RESUMO

INTRODUCTION: the relationship between laparoscopic vertical gastrectomy (LVG) and gastroesophageal reflux (GER) is still controversial. Therefore, its study is of great interest in order to obtain definitive conclusions. The goal of the study was to establish whether LVG modifies pH-metric GER in obese patients and to analyze the associated factors. PATIENTS AND METHODS: the first 26 patients who underwent LVG in our institution were enrolled in the study. A barium swallow, 24-hour ambulatory pH-metry and four-channel intraluminal esophageal manometry (IEM) were all performed before and one year after surgery. RESULTS: among the pH-metric data, there was a significant increase in the DeMeester index after the procedure (p = 0.028), while other parameters remained unchanged. Furthermore, 50% of patients with preoperative pH-metric GER had normal values at one year after surgery. IEM showed a decrease in lower esophageal sphincter (LES) pressure and in the mean wave amplitude at the distal third of the esophagus (p = 0.007 and p = 0.025, respectively). The rate of newly-developed hiatal hernias in the radiographic study was 36.4%. CONCLUSION: LVG mildly increases GER, which is likely related to the development of hiatal hernias and a decrease in LES pressure and esophageal sweep. However, LVG should not be contraindicated for patients with preoperative pH-metric GER, as this may clear after the procedure.


Assuntos
Cirurgia Bariátrica/efeitos adversos , Gastrectomia/efeitos adversos , Refluxo Gastroesofágico/etiologia , Complicações Pós-Operatórias/etiologia , Cirurgia Bariátrica/métodos , Sulfato de Bário , Meios de Contraste , Esfíncter Esofágico Inferior/fisiologia , Monitoramento do pH Esofágico , Feminino , Gastrectomia/métodos , Refluxo Gastroesofágico/diagnóstico , Azia/diagnóstico , Azia/etiologia , Hérnia Hiatal/diagnóstico por imagem , Humanos , Laparoscopia , Masculino , Manometria/métodos , Pessoa de Meia-Idade , Obesidade Mórbida/cirurgia , Complicações Pós-Operatórias/diagnóstico , Estudos Prospectivos
4.
Br J Radiol ; 91(1081): 20170216, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29034693

RESUMO

OBJECTIVE: There is currently no conclusive scientific evidence available regarding the role of the 18F-FDG PET/CT for detecting pulmonary metastases from colorectal cancer (PMCRC) in patients operated on for colorectal liver metastases (CRLM). In the follow up of patients who underwent surgery for CRLM, we compare CT-scan and 18F-FDG PET/CT in patients with PMCRC. METHODS: We designed the study prospectively performing an 18F-FDG PET/CT on all patients operated on for CRLM where the CT-scan detected PMCRC during the follow up. We included patients who were operated on for PMCRC because the histological findings were taken as a control rather than biopsies. RESULTS: Of the 101 pulmonary nodules removed from 57 patients, the CT-scan identified a greater number (89 nodules) than the 18F-FDG PET/CT (75 nodules) (p < 0.001). Sensitivity was greater with the CT-scan (90 vs 76%, respectively) with a lower specificity (50 vs 75%, respectively) than with the 18F-FDG PET/CT. There were no differences between positive-predictive value and negative-predictive value. The 18F-FDG PET/CT detected more pulmonary nodules in four patients (one PMCRC in each of these patients) and more extrapulmonary disease in six patients (four mediastinal lymph nodes, one retroperitoneal lymph node and one liver metastases) that the CT-scan had not detected. CONCLUSION: Although CT-scans have a greater capacity to detect PMCRC, the 18F-FDG PET/CT could be useful in the detection of more pulmonary and extrapulmonary disease not identified by the CT-scan. Advances in knowledge: We tried to clarify the utility of 18F-FDG PET/CT in the management of this subpopulation of patients.


Assuntos
Neoplasias Colorretais/patologia , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/secundário , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Tomografia Computadorizada por Raios X , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Fluordesoxiglucose F18 , Seguimentos , Humanos , Neoplasias Pulmonares/cirurgia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Compostos Radiofarmacêuticos , Sensibilidade e Especificidade
5.
Salud pública Méx ; 57(1): 38-49, ene.-feb. 2015. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-736460

RESUMO

Objetivo. Comparar la salud, uso de servicios sanitarios y necesidad insatisfecha de atención médica (NIAM) entre inmigrantes y nativos del sureste español. Material y métodos. Estudio transversal de dos muestras representativas de población: inmigrante (n=1150) y nativa (n=1303; Encuesta Nacional de Salud). Se creó una única base de datos con ponderación específica para cada muestra y se estimaron razones de prevalencia (RP) mediante regresión multivariante. Resultados. Marroquíes, ecuatorianos y europeos del este (EE) declararon peor salud que los nativos (RPs [IC95%]: 2.45 [1.91-3.15]; 1.51 [1.28-1.79] y 1.44 [1.08-1.93], respectivamente). Los inmigrantes hicieron mayor uso de las urgencias (excepto EE) y consumieron menos fármacos. Los marroquíes mostraron la mayor diferencia en la frecuencia de NIAM (RP [IC95%]: 12.20 [5.25-28.37]), principalmente por razones laborales (46%). Conclusiones. La salud y el uso de servicios sanitarios difirieron significativamente entre inmigrantes y nativos. Destaca la NIAM alta en marroquíes por causa laboral.


Objective. To compare the self-perceived health, use of health services and unmet need for health care (UNHC) among immigrants and native populations of Southeast Spain. Materials and methods. Cross-sectional study of two representative samples of 1150 immigrants, and 1303 native participants from the National Health Survey. A single database was created with specific weights for each sample, and prevalence ratios (PR) were estimated by multivariate regression. Results. Moroccans, Ecuadorians and Eastern Europeans (EE) reported poorer health than the native population (PRs [CI95%]: 2.45 [1.91-3.15]; 1.51 [1.28-1.79] and 1.44 [1.08-1.93], respectively). Immigrants made greater use of emergencies that natives (except for EE) and had lower use of medication. Moroccan showed the greatest difference in the frequency of UNHC (PR [CI95%]:12.20 [5.25 - 28.37]), mainly because of working limitations (46%). Conclusions. The health status and use of health services among immigrants differ significantly from those of natives. Results highlight the higher frequency of UNHC among immigrants, especially high in Moroccans.


Assuntos
Animais , Humanos , Cisteína Endopeptidases/isolamento & purificação , Taenia solium/enzimologia , Cromatografia em Gel , Cromatografia por Troca Iônica , Colágeno/metabolismo , Cisteína Endopeptidases/química , Cisteína Endopeptidases/metabolismo , Inibidores de Cisteína Proteinase/farmacologia , Imunoglobulina G/metabolismo , Ácido Iodoacético/farmacologia , Leucina/análogos & derivados , Leucina/farmacologia , Soroalbumina Bovina/metabolismo
6.
Salud Publica Mex ; 57(1): 38-49, 2015.
Artigo em Espanhol | MEDLINE | ID: mdl-25629278

RESUMO

OBJECTIVE: To compare the self-perceived health, use of health services and unmet need for health care (UNHC) among immigrants and native populations of Southeast Spain. MATERIALS AND METHODS: Cross-sectional study of two representative samples of 1150 immigrants, and 1303 native participants from the National Health Survey. A single database was created with specific weights for each sample, and prevalence ratios (PR) were estimated by multivariate regression. RESULTS: Moroccans, Ecuadorians and Eastern Europeans (EE) reported poorer health than the native population (PRs [CI95%]: 2.45 [1.91-3.15]; 1.51 [1.28-1.79] and 1.44 [1.08-1.93], respectively). Immigrants made greater use of emergencies that natives (except for EE) and had lower use of medication. Moroccan showed the greatest difference in the frequency of UNHC (PR [CI95%]:12.20 [5.25 - 28.37]), mainly because of working limitations (46%). CONCLUSIONS: The health status and use of health services among immigrants differ significantly from those of natives. Results highlight the higher frequency of UNHC among immigrants, especially high in Moroccans.


Assuntos
Emigrantes e Imigrantes , Pesquisas sobre Atenção à Saúde , Necessidades e Demandas de Serviços de Saúde , Serviços de Saúde/estatística & dados numéricos , Disparidades em Assistência à Saúde , Assistência Médica/estatística & dados numéricos , Adolescente , Adulto , Estudos Transversais , Uso de Medicamentos/estatística & dados numéricos , Equador/etnologia , Serviços Médicos de Emergência/estatística & dados numéricos , Europa (Continente)/etnologia , Feminino , Acesso aos Serviços de Saúde/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Marrocos/etnologia , Ocupações/estatística & dados numéricos , Espanha , Adulto Jovem
7.
J Occup Health ; 56(1): 39-48, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24430840

RESUMO

OBJECTIVES: Despite the great impact the migration has had in economic, social and health-related fields, and the repercussions of alcohol consumption on them, few data exist concerning the extent of alcohol consumption in migrant workers. The aims of this study were to identify workers with a hazardous drinking problem by means of a self-reported questionnaire (Alcohol Use Disorders Identification Test-AUDIT) and a biomarker (carbohydrate-deficient transferrin-CDT) and to ascertain associated risk factors. METHODS: A cross-sectional survey was conducted using a random sample of 385 migrant workers, undergoing a routine health examination as part of occupational health services. RESULTS: The results showed that 13.8% (n=53) of the workers were screened as positive with the AUDIT (≥8) and/or CDT (>2.6) and identified as hazardous drinkers and that 53.8% (n=207) were teetotallers. Being a man (OR: 2.0), working in the construction industry (OR: 2.8) or agriculture (OR: 2.2), being resident in Spain for more than 7 years (OR: 2.3) and sharing a house with friends were the factors most closely associated with hazardous drinking. CONCLUSIONS: Prevention-orientated programs, adjusted to the characteristics of each country and the origin of the migrants themselves, should be instituted to modify the drinking habits of migrant workers considered at risk.


Assuntos
Agricultura/estatística & dados numéricos , Consumo de Bebidas Alcoólicas/etnologia , Indústria da Construção/estatística & dados numéricos , Migrantes/estatística & dados numéricos , Adolescente , Adulto , Distribuição por Idade , Idoso , Biomarcadores/sangue , Estudos Transversais , Características da Família , Feminino , Humanos , Modelos Logísticos , Masculino , Programas de Rastreamento/métodos , Programas de Rastreamento/estatística & dados numéricos , Pessoa de Meia-Idade , Ocupações/classificação , Ocupações/estatística & dados numéricos , Exame Físico , Prevalência , Fatores de Risco , Autorrelato , Distribuição por Sexo , Espanha/epidemiologia , Inquéritos e Questionários , Fatores de Tempo , Transferrina/análogos & derivados , Transferrina/análise , Adulto Jovem
8.
Cir. Esp. (Ed. impr.) ; 87(2): 82-88, feb. 2010. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-80053

RESUMO

Introducción La indicación de trasplante hepático (TH) en el tumor de Klatskin (TK) no está establecida debido a la discrepancia en los resultados de las series publicadas. Objetivo Presentar los resultados del TH en pacientes con TK irresecable no diseminado y compararlos con los obtenidos en los pacientes no resecados y con resección del tumor. Pacientes y método Hemos tratado 75 pacientes con TK. La edad media fue de 62±11 años (rango: 38–88) y 50 fueron varones (66%). Veinte pacientes se consideraron inoperables. Se realizó resección del tumor (RT) en 29 de los 55 pacientes operados, TH en 11 casos (en tumores irresecables no diseminados) y tratamiento paliativo en los 15 pacientes con TK irresecables diseminados. Resultados En el grupo TH no hubo mortalidad postoperatoria (primer mes) y presentaron una supervivencia a 1, 3 y 5 años del 95, el 59 y el 36% con una supervivencia libre de enfermedad (SLE) del 75, el 40 y el 20%. Los pacientes con RT presentaron una supervivencia del 80, el 52 y el 38%, con una SLE del 65, el 35 y el 19%, sin diferencias respecto al grupo TH. Los pacientes con tumor irresecable que quedaron con tratamientos paliativos presentaron una supervivencia inferior a la de los pacientes con tumores irresecables que recibieron TH (p<0,001).Conclusiones En pacientes con TK irresecable no diseminado, el TH consigue una supervivencia similar a la obtenida en los casos resecables con la resección hepática R0, y mejora claramente la esperanza de vida de estos pacientes con tratamientos paliativos (AU)


Introduction There are no established indications for Liver transplant (LT) in patients with a Klatskin tumour (KT) due to the differences in the published results. Objective To report on our patients who have non-disseminated unresectable KT and who were given a LT, and to compare results with those of patients who have had tumour resection and those who have not. Patients and method We have treated 75 patients diagnosed with KT. The mean age was 62±11 years (range: 38–88 years) and 50 were males (66%). Twenty patients were inoperable. Of the 55 patients who underwent surgery: tumour resection (TR) was performed in 29 cases; there was no tumour dissemination in 11 unresectable cases and therefore these patients were added to the LT waiting list and the remaining 15 unresectable cases had tumour dissemination and remained on palliative treatment.ResultsIn the LT group there was no postoperative mortality (during the first month) and the survival rate was 95%, 59% and 36% with a disease-free survival of 75%, 40% and 20%; whereas the patients given RT had a survival rate of 80%, 52% and 38% at 1, 3 and 5 years, with a disease-free survival of 65%, 35% and 19%, without any differences compared to the LT group. Patients with unresectable tumour left on palliative therapy had a lower survival than the unresectable who underwent LT (p<0.001).Conclusions In patients with non-disseminated unresectable KT, LT has a similar survival to that obtained in cases with resectable R0 liver resection. LT improves the survival rate achieved using palliative treatment in patients with non-disseminated unresectable KT (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias dos Ductos Biliares/mortalidade , Neoplasias dos Ductos Biliares/cirurgia , Tumor de Klatskin/mortalidade , Tumor de Klatskin/cirurgia , Transplante de Fígado , Ducto Colédoco , Taxa de Sobrevida
9.
Cir Esp ; 87(2): 82-8, 2010 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-20074713

RESUMO

INTRODUCTION: There are no established indications for Liver transplant (LT) in patients with a Klatskin tumour (KT) due to the differences in the published results. OBJECTIVE: To report on our patients who have non-disseminated unresectable KT and who were given a LT, and to compare results with those of patients who have had tumour resection and those who have not. PATIENTS AND METHOD: We have treated 75 patients diagnosed with KT. The mean age was 62 + or - 11 years (range: 38-88 years) and 50 were males (66%). Twenty patients were inoperable. Of the 55 patients who underwent surgery: tumour resection (TR) was performed in 29 cases; there was no tumour dissemination in 11 unresectable cases and therefore these patients were added to the LT waiting list and the remaining 15 unresectable cases had tumour dissemination and remained on palliative treatment. RESULTS: In the LT group there was no postoperative mortality (during the first month) and the survival rate was 95%, 59% and 36% with a disease-free survival of 75%, 40% and 20%; whereas the patients given RT had a survival rate of 80%, 52% and 38% at 1, 3 and 5 years, with a disease-free survival of 65%, 35% and 19%, without any differences compared to the LT group. Patients with unresectable tumour left on palliative therapy had a lower survival than the unresectable who underwent LT (p<0.001). CONCLUSIONS: In patients with non-disseminated unresectable KT, LT has a similar survival to that obtained in cases with resectable R0 liver resection. LT improves the survival rate achieved using palliative treatment in patients with non-disseminated unresectable KT.


Assuntos
Neoplasias dos Ductos Biliares/mortalidade , Neoplasias dos Ductos Biliares/cirurgia , Ducto Hepático Comum , Tumor de Klatskin/mortalidade , Tumor de Klatskin/cirurgia , Transplante de Fígado , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Taxa de Sobrevida
10.
Cir Esp ; 85(1): 32-9, 2009 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-19239935

RESUMO

INTRODUCTION: There are many studies that analyse preoperative factors with a poor prognosis in patients undergoing surgery for colorectal carcinoma liver metastases, in order to avoid unnecessary surgery. However, there are few studies that evaluate the intraand postoperative prognostic factors. The aim of this study is to analyse pre-, intra- and postoperative prognostic factors in a series of 210 patients undergoing surgery for colorectal carcinoma liver metastases, with special emphasis on the postoperative factors that can give us information on the aggressiveness of the tumour and the curative effectiveness of the surgery. PATIENTS AND METHOD: Between September 1996 and December 2006, 210 patients undergoing surgery for colorectal carcinoma liver metastases in whom we analysed pre-, intra- and postoperative factors of survival. Mean follow-up was 55+/-3 months (range: 12-124 months). RESULTS: The postoperative mortality rate was 1.4% and the morbidity rate was 22%. Actuarial and disease-free survival at 1-, 3- and 5-years was 89.9% vs 63%, 66.9% vs 32%, and 53.8% vs 23%, respectively. Among the preoperative factors analysed, the age>65 years and LM size>5 cm were independent predictors of poor overall survival, whereas the other two significant factors were obtained from those analysed postoperatively: presence of microsatellitosis and postoperative CEA levels (at 1 and 3 months). CONCLUSIONS: In patients with colorectal carcinoma liver metastases we must take into account certain postoperative factors that can give us information on the aggressiveness of the tumour and the effectiveness of the surgery.


Assuntos
Neoplasias Colorretais/patologia , Neoplasias Hepáticas/secundário , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Neoplasias Hepáticas/mortalidade , Masculino , Pessoa de Meia-Idade , Prognóstico , Taxa de Sobrevida , Adulto Jovem
11.
Endocrinology ; 150(7): 3118-27, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19179436

RESUMO

Chronic opiate exposure induces neurochemical adaptations in the noradrenergic system. Enhanced responsiveness of the hypothalamo-pituitary-adrenal axis after morphine withdrawal has been associated with hyperactivity of ascending noradrenergic input from the nucleus of the solitary tract (NTS-A(2)) cell group to the hypothalamic paraventricular nucleus (PVN). This study addressed the role of morphine withdrawal-induced corticosterone (CORT) release in regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis in adrenalectomized (ADX) rats supplemented with low CORT pellet (ADX plus CORT). Present results show that in sham-ADX rats, noradrenergic neurons in the NTS-A(2) became activated during morphine withdrawal, as indicated by increased TH mRNA expression. However, this induction of TH expression is not detected in ADX plus CORT rats that are unable to mount CORT secretory response to morphine withdrawal. Total TH protein levels were elevated in the NTS-A(2) from sham-operated rats during morphine dependence and withdrawal, whereas we did not find any alteration in ADX plus CORT animals. Furthermore, high levels of TH phosphorylated (activated) at Ser31 (but not at Ser40) were found in the A(2) area from sham-morphine withdrawn rats. Consistent with these effects, we observed an increase in the enzyme activity of TH in the PVN. However, induction of morphine withdrawal to ADX plus CORT animals did not alter the phosphorylation (activation) of TH in NTS-A(2) and decreased TH activity in the PVN. These results suggest the existence of a positive reverberating circle in which elevated glucocorticoids during morphine abstinence play a permissive role in morphine withdrawal-induced activation of noradrenergic pathway innervating the PVN.


Assuntos
Corticosterona/metabolismo , Morfina/efeitos adversos , Núcleo Hipotalâmico Paraventricular/metabolismo , Síndrome de Abstinência a Substâncias/metabolismo , Tirosina 3-Mono-Oxigenase/genética , Adrenalectomia , Hormônio Adrenocorticotrópico/sangue , Animais , Hidrocortisona/sangue , Masculino , Dependência de Morfina/fisiopatologia , Fosforilação , RNA Mensageiro/metabolismo , Ratos , Ratos Wistar , Redução de Peso/efeitos dos fármacos
12.
Cir. Esp. (Ed. impr.) ; 85(1): 32-39, ene. 2009. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-59340

RESUMO

Introducción: numerosos estudios han analizado los factores de mal pronóstico preoperatorios en pacientes sometidos a resección hepática por metástasis hepáticas de cáncer colorrectal(MHCCR) con el fin de seleccionar a los pacientes para tratamiento quirúrgico. Sin embargo, los factores intraoperatorios y postoperatorios han sido poco analizados. El objetivo de este estudio es determinar los factores preoperatorios, intraoperatorios y postoperatorios en una serie de 210 pacientes intervenidos por MHCCR, con especial énfasis en los factores postoperatorios, que podrían informar acerca de la agresividad del tumor y de la eficacia curativa de la cirugía realizada. Pacientes y método: realizamos un estudio prospectivo en 210 pacientes intervenidos de MHCCR entre septiembre de 1996 y diciembre de 2006, en el que analizamos factores de supervivencia preoperatorios, intraoperatorios y postoperatorios. El seguimiento fue de 55± 3 (intervalo, 12-124) meses. Resultados: la mortalidad postoperatoria fue del 1,4% y la morbilidad, del 22%. Las supervivencias actuariales frente a intervalos libres de enfermedad a 1, 3 y 5 años fueron del 89,9frente al 63%, el 66,9 frente al 32% y el 53,8 frente al 23%, respectivamente. Entre los factores preoperatorios analizados, la edad > 65 años y el tamaño de la metástasis > 5 cm fueron factores de mal pronóstico independientes, mientras que dos factores significativos de mal pronóstico fueron obtenidos del análisis postoperatorio: microsatelitosis y cifras postoperatorias de CEA > 5 ng/ml (a 1 y 3 meses).Conclusiones: en pacientes con MHCCR es necesario tener en cuenta los factores postoperatorios que pueden informarnos acerca de la agresividad del tumor y de la eficacia de la cirugía (AU)


Introduction: There are many studies that analyse preoperative factors with a poor prognosis in patients undergoing surgery for colorectal carcinoma liver metastases, in order to avoid unnecessary surgery . However, there are few studies that evaluate the intra and postoperative prognostic factors. The aim of this study is to analyse pre-, intra- and postoperative prognostic factors in a series of 210 patients undergoing surgery for colorectal carcinoma liver metastases, with special emphasis on the postoperative factors that can give us information on the aggressiveness of the tumour and the curative effectiveness of the surgery. Patients and method: Between September 1996 and December 2006, 210 patients undergoing surgery for colorectal carcinoma liver metastases in whom we analysed pre-, intra- and postoperative factors of survival. Mean follow-up was 55±3 months (range: 12-124 months).Results: The postoperative mortality rate was 1.4% and the morbidity rate was 22%.Actuarial and disease-free survival at 1-, 3- and 5-years was 89.9% vs 63%, 66.9% vs 32%,and 53.8% vs 23%, respectively. Among the preoperative factors analysed, the age >65 years and LM size >5 cm were independent predictors of poor overall survival, whereas the other two significant factors were obtained from those analysed postoperatively: presence of microsatellitosis and postoperative CEA levels (at 1 and 3 months).Conclusions: In patients with colorectal carcinoma liver metastases we must take into account certain postoperative factors that can give us information on the aggressiveness of the tumour and the effectiveness of the surgery (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Hepáticas/secundário , Neoplasias Hepáticas/cirurgia , Neoplasias Colorretais/patologia , Estudos Prospectivos , Fatores de Risco , Prognóstico , Análise de Sobrevida
14.
Aten Primaria ; 39(1): 23-8, 2007 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-17286920

RESUMO

OBJECTIVES: To examine the attitudes of family doctors to patients' rights and to ascertain the social and professional variables that influence these views. DESIGN: Descriptive, cross-sectional study based on a questionnaire. SETTING: Primary care, Murcia, Spain. PARTICIPANTS: Two-hundred and twenty-seven family physicians, who filled in a postal questionnaire. INTERVENTIONS: The questionnaire included social and professional variables, evaluation of job satisfaction (by Likert scale 1-5), evaluation of patients' rights (Likert scale 1-5). MAIN MEASUREMENTS AND RESULTS: The most valued right in the overall view of the doctors questioned was the right to suitable health care within a humane framework (4.86; 95% CI, 4.81-4.91), while the least valued right was the access to medical records (3.91; 95% CI, 3.76-4.05). Mean job satisfaction was 2.79 (95% CI, 2.71-2.87). We found: statistically significant differences in the assessment of patients' rights, which depended on various social and professional factors; direct associations between doctors' satisfaction and their views on patients' rights; and a significant correlation between overall evaluation of rights and total satisfaction (P=.039). CONCLUSIONS: Overall, family doctors attach a lot of importance to patients' rights. However, social and professional characteristics seem to have some influence on their attitudes: older doctors, those working in an urban context, those with few patients on their lists, in teaching centres, and those feeling the greatest professional satisfaction tend to attach greater importance to patients' rights.


Assuntos
Atitude do Pessoal de Saúde , Medicina de Família e Comunidade , Direitos do Paciente , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
15.
Aten. prim. (Barc., Ed. impr.) ; 39(1): 23-28, ene. 2007. tab
Artigo em Es | IBECS | ID: ibc-051583

RESUMO

Objetivo. Conocer las actitudes de los médicos de familia hacia los derechos del paciente y las variables socioprofesionales que pueden influir en ellas. Diseño. Descriptivo, transversal, basado en la aplicación de un cuestionario. Emplazamiento. Atención primaria de Murcia. Participantes. En total, 227 médicos de familia. Intervenciones. El cuestionario se envió por correo e incluía variables socioprofesionales, así como una valoración de la satisfacción profesional y de la importancia de los derechos del paciente (mediante escalas tipo Likert). Mediciones principales y resultados. Los profesionales conceden la mayor valoración al derecho a una asistencia adecuada en el plano humano (4,86; intervalo de confianza [IC] del 95%, 4,81-4,91), mientras que el acceso a la historia clínica es el derecho menos valorado (3,91; IC del 95%, 3,76-4,05). La media de la satisfacción total es de 2,79 (IC del 95%, 2,71-2,87). Se observan diferencias estadísticamente significativas en la valoración de los derechos de los pacientes según las distintas características sociolaborales y la satisfacción profesional. Hay una correlación significativa entre la valoración total de los derechos y la satisfacción profesional global (p = 0,039). Conclusiones. La valoración global de la importancia que conceden los médicos de familia a los derechos de los pacientes es muy alta. Los médicos de más edad, que trabajan en el ámbito urbano, con menos tarjetas sanitarias asignadas, en centros docentes y con una mayor satisfacción profesional, conceden una mayor importancia a los derechos de los pacientes


Objectives. To examine the attitudes of family doctors to patients' rights and to ascertain the social and professional variables that influence these views. Design. Descriptive, cross-sectional study based on a questionnaire. Setting. Primary care, Murcia, Spain. Participants. Two-hundred and twenty-seven family physicians, who filled in a postal questionnaire. Interventions. The questionnaire included social and professional variables, evaluation of job satisfaction (by Likert scale 1-5), evaluation of patients' rights (Likert scale 1-5). Main measurements and results. The most valued right in the overall view of the doctors questioned was the right to suitable health care within a humane framework (4.86; 95% CI, 4.81-4.91), while the least valued right was the access to medical records (3.91; 95% CI, 3.76-4.05). Mean job satisfaction was 2.79 (95% CI, 2.71-2.87). We found: statistically significant differences in the assessment of patients' rights, which depended on various social and professional factors; direct associations between doctors' satisfaction and their views on patients' rights; and a significant correlation between overall evaluation of rights and total satisfaction (P=.039). Conclusions. Overall, family doctors attach a lot of importance to patients' rights. However, social and professional characteristics seem to have some influence on their attitudes: older doctors, those working in an urban context, those with few patients on their lists, in teaching centres, and those feeling the greatest professional satisfaction tend to attach greater importance to patients' rights


Assuntos
Humanos , Direitos do Paciente/tendências , Médicos de Família , Relações Médico-Paciente , Satisfação no Emprego , Pesquisas sobre Atenção à Saúde/estatística & dados numéricos , Atenção Primária à Saúde/estatística & dados numéricos , Acesso dos Pacientes aos Registros/tendências , Epidemiologia Descritiva
16.
Rev. esp. geriatr. gerontol. (Ed. impr.) ; 41(supl.1): 7-14, nov. 2006. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-151239

RESUMO

Introducción: detectar la discapacidad e identificar factores asociados debe ser un objetivo fundamental en atención primaria de salud como primer paso para prevenir la dependencia. Se estudia la prevalencia de discapacidad funcional en un grupo de mayores de 65 años demandante de atención sanitaria, definiendo el perfil de sujeto dependiente en las actividades básicas de la vida diaria (ABVD). Material y métodos: estudio descriptivo transversal. La muestra se obtuvo del conjunto de pacientes que acuden demandando asistencia sanitaria a centros de salud de la Región de Murcia. La capacidad funcional para ABVD (índice de Katz) se relaciona con distintas variables sociodemográficas. Resultados: se evaluó a 460 sujetos (53,3% mujeres), con una edad media de 74,1 años (desviación estándar: 5,7). El 27,8% de los sujetos presenta dependencia para alguna de las ABVD: desde el 23,5% que necesita ayuda para vestirse, hasta el 11,7% para alimentarse. El 11,1% presenta dependencia para todas las ABVD. Existe una asociación estadísticamente significativa entre dependencia y edad avanzada, ser viudo, residir en casa de otros familiares, mayoritariamente hijos, en zonas semiurbanas, y percibir menores ingresos (p < 0,05). No hubo asociación entre dependencia y sexo o escolaridad. Conclusiones: la mayoría de los sujetos mayores de 65 años de la muestra tienen una excelente capacidad funcional. Tratándose de pacientes que pueden acudir a la consulta, una cuarta parte presenta limitación en la realización de alguna de las ABVD. La independencia funcional se asocia a tener menos edad, vivir en pareja en el domicilio propio y percibir mayores ingresos (AU)


Introduction: detecting incapacity and identifying associated factors should be among the principal concerns of primary care as a first step in preventing dependence. The aims of this study were to determine the prevalence of functional incapacity by using the Katz index in patients aged 65 years and older seeking medical attention and to define the profile of persons dependent for basic activities of daily living (BADL). Material and methods: a descriptive, cross-sectional study was performed. The sample was obtained from all patients attending a primary care centre in the region of Murcia (Spain). Functional capacity in BADL (Katz index) was assessed and various sociodemographic variables were recorded. Results: four-hundred sixty patients (53.3% women) were assessed. The mean age was 74.1% (SD: 5.7). A total of 27.8% of the patients were assessed as dependent for at least one BADL, the highest figure being for those in need of help to dress themselves (23.5%) and the lowest for feeding (11.7%). Dependence for all BADL was found in 11.1%. A statistically significant association was found between functional capacity and old age, widowhood, living in the home of relatives, usually their own children, living in semi-urban areas, and having a low income (p < 0.05). No correlation was found between dependence and gender or educational level. Conclusions: most patients aged more than 65 years old in the sample had excellent functional capacity. Although all the patients were able to attend the centre, 27.8% had some limitation in performing BADL. The best functional capacity was associated with lower age, living in a couple, and having a high income (AU)


Assuntos
Humanos , Masculino , Feminino , Idoso , Idoso de 80 Anos ou mais , Geriatria/educação , Geriatria/ética , Osteogênese Imperfeita/genética , Osteogênese Imperfeita/patologia , Envelhecimento/metabolismo , Escalas de Graduação Psiquiátrica/normas , Espanha , Estudos Transversais/métodos , Geriatria , Geriatria/métodos , Osteogênese Imperfeita/complicações , Osteogênese Imperfeita/diagnóstico , Dependência Psicológica , Envelhecimento/patologia , Epidemiologia Descritiva
17.
Diabetes Res Clin Pract ; 71(2): 202-9, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16107290

RESUMO

The aim of this cross-sectional study was to describe the prevalence of total, known and unknown diabetes mellitus and impaired fasting glucose (IFG) in the population of Murcia (SE Spain), a Mediterranean area with a high prevalence of obesity. Therefore, 2562 subjects (>or=20 years) were selected by stratified random sampling and a survey was carried out by telephone, together with a physical examination and biochemical determinations. The ADA-1997 diagnostic criteria were used. The crude prevalence of total diabetes was 11% (9.5-12.6%), known diabetes 7.8% (6.5-9.2%), unknown diabetes 3.2% (2.4-4.2%) and IFG 4.9% (3.9-6.1%). Both total diabetes and IFG were higher in men than in women, with prevalence rates increasing with age. People with diabetes and IFG had higher BMI, blood pressure, total cholesterol, LDL-cholesterol and triglyceride values than the rest of the population. No difference in the prevalence of diabetes was observed between the rural and urban populations. The prevalence of diabetes in Murcia is high compared to the rest of Spain and the world, suggesting that the possible benefits attributed to some characteristics of the diet of this Mediterranean population are not sufficient to counteract the risk factors associated with the disease.


Assuntos
Diabetes Mellitus/epidemiologia , Obesidade/epidemiologia , Adulto , Idoso , Glicemia/metabolismo , Feminino , Humanos , Masculino , Região do Mediterrâneo/epidemiologia , Pessoa de Meia-Idade , Prevalência , População Rural , Caracteres Sexuais , Espanha/epidemiologia , Inquéritos e Questionários , População Urbana
18.
AJR Am J Roentgenol ; 182(1): 155-9, 2004 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-14684530

RESUMO

OBJECTIVE: The objective of this study was to compare the diagnostic value of panoramic and conventional radiography in the detection of fractures of the carpal scaphoid bone. MATERIALS AND METHODS: Panoramic (orthopantomographic) and conventional radiographs of 90 patients with acute or chronic wrist trauma were reviewed retrospectively. Images were analyzed and reviewed independently by four observers: two radiologists and two traumatologists. The kappa statistic was used to calculate intraand interobserver agreement and the correlation between the two imaging techniques. RESULTS: Panoramic radiography of the wrist was superior to conventional radiography in ruling out scaphoid fractures (74%, 20/27) in patients with suspicious findings on conventional radiography; revealed more cases of scaphoid fractures (21.4%, 12/56); and revealed more cases of delayed union (n = 2), nonunion (n = 3), and union (n = 3). Agreement values were higher, with better inter- and intraobserver agreement, for the panoramic examinations than for the conventional radiographic examinations. CONCLUSION: The panoramic examination of the wrist is a useful technique for the diagnosis and follow-up of scaphoid fractures. Its use is recommended as a complement to conventional radiography in cases with inconclusive findings.


Assuntos
Fraturas Ósseas/diagnóstico por imagem , Radiografia Panorâmica , Osso Escafoide/diagnóstico por imagem , Osso Escafoide/lesões , Traumatismos do Punho/diagnóstico por imagem , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Estudos Retrospectivos
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